Fountain of Youth - Technical

TECHNICAL DATA: Appearance: Fine, free-flowing powder Color: Brown to dark brown Odor: Characteristic Identity: High-performance thin-layer chromatogram (HPTLC) and high-performance liquid chromatogram (HPLC) Water-soluble extractive value: = 80% (w/w) Product Availability Suggested use level 250 mg to 500 mg per day Analytical Profile Specifications Total Dibenzo-a-pyrones = 0.30% (w/w) (HPTLC) Dibenzo-a-pyrone Chromo proteins = 10% (w/w) (Gravimetric) Fulvic acids and equivalents = 60% (w/w) (Gravimetric) Water = 6% (w/w) (Karl Fischer) E4/E6 at 465/665 nm 5 to 9.5 Heavy metals Lead (Pb) = 0.0005% Arsenic (As) = 0.0002% Mercury (Hg) = 0.0001% pH (2% aqueous dispersion) = 5 Microbiological Profile Aerobic bacteria = 5000 CFU/g Yeast and mold = 1000 CFU/g Escherichia coli absent in 1 g Pseudomonas aeruginosa absent in 1 g Staphylococcus aurous absent in 1 g Salmonella species absent in 10 g Candida albicans absent in 1 g Additional Data Storage: Store in original, sealed containers at 15° to 25 °C; avoid light Stability: Minimum 2 years

Fountain of Youth - FAQ

What is Alivamax Fountain of Youth? Alivamax Fountain of Youth is a patented purified form of Shilajit known as Alivamax Shilajit. It is a standardized Shilajit dietary supplement (protected under Five U.S. Patents and additional pending U.S. and foreign patents) developed to provide energy to the body and mind.

Who is behind the development of Alivamax Shilajit? Alivamax Shilajit is the ultimate Shilajit extract established by Dr. Shibnath Ghosal, who is a well respected Chief Science Officer. Dr. Ghosal is a world-renowned natural-product scientist who has been studying Shilajit for more than 30 years.

Why is Alivamax Shilajit™ so Unique? The bioactives present in Shilajit have survived hundreds of millions of years of evolution. These bioactives are still present in humans and other animals and provide an energy source. These discoveries have led many scientists to believe that the bioactives found in Shilajit may be essential for the existence of life on earth.

What sets the Alivamax Shilajit apart from others? Regular Shilajit is a pale brown to blackish-brown exudation of variable consistencies, found in fissures of sedimentary rocks high in the Himalayan Mountains, at altitudes of 1,000 to 5,000 meters. Unfortunately, regular Shilajit has no chemical definition. It is well-known that ill-defined dietary-supplement ingredients of natural origin can vary significantly from one another with respect to bioactive constituents; hence the performance and safety also varies. With Alivamax Shilajit™, we are able to guarantee only the most potent and safest Shilajit for use in dietary-supplement or health formulations. The Shilajit in Alivamax Shilajit™ is obtained from carefully selected Shilajit-bearing rocks. It is then put through patented technology, which produces a consistent purified and standardized compound, assuring optimal levels of bioactive components.

What is the primary function of Alivamax Shilajit? Alivamax Shilajit assists in the maintenance and regeneration of normal physiological functions by acting as an energy currency or biocatalyst in the body.

Does Alivamax Shilajit™ provide any benefits other than energy enhancement? Modern research has shown that Shilajit increases immunity, strength, and endurance; it strengthens cognitive ability, heightens libido, and functions as a transporter/carrier to more efficiently drive other nutrients into the body. As an adaptogen, it helps reduce stress, strengthen the immune system, and reduce allergies.

What is an adaptogen? By definition, an adaptogen is a substance that: • Demonstrates nonspecific balancing effects, such as increased resistance to physical or biological stressors • Possesses a normalizing influence on the body and mind • Does not disturb functions already within a normal range As an adaptogen, shilajit provides vitality and well-being by restoring lost DBPs and DCPs. It also balances and normalizes functions such as blood pressure, hormone levels, energy production, and digestion.

Is Alivamax Shilahit safe? Yes. Alivamax Shilajit has been tested under a stringent safety-and-control-processing method. The following heavy metals of less than 1 ppm were found: Lead (Pb) = 0.002% Arsenic (As) = 0.0005% Mercury (Hg) = 0.0001%

What form does Alivamax Shilajit come in? Alivamax Shilajit comes in a fine, free-flowing powder in a vegetable capsule.

Allergies

Ghosal, S., et al, "Mast Cell Protecting Effects of Shilajit and Its Constituents," Phytotherapy Research, 3 (6): 249-252, 1989.

Albino rats were sensitized to horse serum every day for 14 days. The test group was given processed shilajit. On the fourteenth day, the subjects were tested for mast cell degranulation. When mast cells degranulate, they release histamine, which causes inflammation, resulting in the characteristic runny nose and watery eyes of allergic reactions. The shilajit-treated subjects' mast cells had significantly less degranulation. Less histamine was released, and fewer allergic symptoms resulted. There were also no perceptible toxic effects with dosages ranging from 100 mg/kg to 500 mg/kg, equivalent to approximately 68 grams for a 150-pound person.

Anti-inflammatory

Goel, R.K., et al, "Anti-ulcerogenic and Anti-inflammatory Studies With Shilajit," Journal of Ethnopharmacology, 29: 95-103, 1990.

Albino rats were given injections of potassium carrageenan to induce inflammation in their hind paws. The paws were measured for fluid volume before and, at timed intervals, after injection. Shilajit, at a dose of 50 mg/kg, reduced chemically induced inflammation by 77 percent.

Antioxidant

Ghosal, S., et al, "Interaction of Shilajit With Biogenic Free Radicals," Department of Pharmaceutics, Banaras Hindu University, Varanasi-221005, India

Processed shilajit was tested for its ability to neutralize sulfite anion (SO), hydroxyl (HO), and nitric oxide (NO) free radicals. Chemical polymerization by free radicals was measured with and without processed shilajit. It provided almost complete protection of methyl methacrylate (MMA) against HO-radical-induced polymerization and significantly inhibited the polymerization of MMA by the SO free radicals. Processed shilajit efficiently trapped NO free radicals. The antioxidant effects were concentration-dependent. Higher concentrations of processed shilajit provided greater free-radical protection.

Ghosal, S., et al, "Antioxidant Defense by Native and Processed Shilajit - A Comparative Study," Indian Journal of Chemistry, 35B: 127-132, 1996.

The antioxidant potential of processed shilajit was compared to unprocessed shilajit and vitamin C (ascorbic acid). Peak levels of shilajit occurred 12 to 15 hours after ingestion and took more than 72 hours to metabolize. Processed shilajit showed significant antioxidant activity. It also exhibited the ability to regenerate ascorbic acid after it neutralized free radicals. The dihydroxybenzo-alpha-pyrones in shilajit recycled ascorbic acid. Unprocessed shilajit did not consistently exhibit antioxidant activity.

Diabetes

Bhattacharya, S.K., et al, "Shilajit Attenuates Streptozotocin-Induced Diabetes Mellitus and Decreases Pancreatic Islet Superoxide Dismutase Activity in Rats," Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Science, Banaras Hindu University, Varanasi-221005, India

Diabetes mellitus was experimentally induced in albino rats by the administration of streptozotocin. The disease resulted in an increase of superoxide free radicals and free-radical damage to the pancreas. From the fourteenth day on, there was significant hyperglycemia, or high blood sugar, due to a lack of insulin. The test groups were given 50 mg/kg or 100 mg/kg. The shilajit had no effect on normal blood sugar levels. It stopped the progression of hyperglycemia with statistically significant changes among the 100 mg/kg group. There was also a decrease in superoxide-free-radical damage owing to the antioxidant effects of shilajit.

General

Ghosal, S., et al, "The Need for Formulation of Shilajit by Its Isolated Active Constants," Phytotherapy Research, 5: 211-216, 1991.

Unprocessed shilajit samples collected from India, Nepal, Pakistan, and the Soviet Union were compared to a processed shilajit extract for their respective antistress and central nervous system effects. The processed shilajit extract produced consistently better results than the unprocessed shilajit. Stress was induced by forced swimming immobility on albino rats for six minutes. The treated rats recovered more quickly than the nontreated rats, with the processed shilajit producing the best results. Albino rats given shilajit extract resisted aspirin-induced ulcers significantly better than the control group, which received no shilajit, and the group that was fed unprocessed shilajit. The therapeutic properties of shilajit vary by region. To provide a consistent level of active ingredients, processing and standardization is necessary.

Immunity

Ghosal, S., et al, "Shilajit-Induced Morphometric and Functional Changes in Mouse Peritoneal Macrophages," Department of Pharmaceutics, Banaras Hindu University, Varanasi-221005, India

Mice were given either a shilajit extract or a placebo. Their white blood cell activity was monitored prior to and, at intervals, after receiving the shilajit extract or placebo. The shilajit extract increased white blood cell activity, which rose in accordance with the dosage and the time that elasped after exposure.

Ghosal, S., "Chemistry of Shilajit, an Immunomodulatory Ayurvedic Rasayan," Pure and Applied Chemistry, 62 (7): 1285-1288, 1990.

The low-molecular-weight oxygenated dibenzo-alpha-pyrones and triterpenic acid (humic and fulvic acids) are the major active ingredients of shilajit. They affect the endocrine, autonomic, and central nervous systems, bringing about an immunomodulating result by increasing the activity of macrophages.

Bhatineharyn, S.K., "Effect of Shilajit on Rat Brain Monoamines," Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi-221005, India Ghosal, S., Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-2210052, India

Male albino rats were divided into four groups:

• Control
• Shilajit extract (50mg/kg) one hour prior to evaluation
• Shilajit extract (25mg/kg) daily five hours before evaluation
• Shilajit extract (50mg/kg) daily five hours before evaluation

Neurotransmitter, serotonin, dopamine, and noradrenaline levels were measured and compared to the control group. The rats in the fourth group exhibited neurotransmitter changes associated with increased humoral, or immune, system response compared with that of the other groups. The rats in the third group experienced some improvement in neurotransmitter activity, but it was not as significant as the fourth group's.

Memory

Ghosal, S., et al, "Effects of Shilajit and Its Active Constituents on Learning and Memory in Rats," Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi-221005, India

Lab rats were given processed shilajit, raw shilajit, or fulvic acid (derived from shilajit). The rats were then tested in a maze and a mild electric-shock-avoidance environment. The rats that were fed the processed shilajit learned to evade electric shocks more quickly and took less time to learn the maze than the control subjects did.

Ulcer

Goel, R.K., "Anti-ulcerogenic and Anti-inflammatory Studies With Shilajit," Journal of Ethnopharmacology, 29: 95-103, 1990.

Albino rats and male guinea pigs were given aspirin to induce gastric ulcers. The subjects that were fed shilajit had fewer incidences of ulcers. When the gastric juices were analyzed, researchers found a significant increase in the carbohydrate-protein ratio, which indicates a rise in protective mucosal secretions. The subjects that consumed shilajit were protected from ulcers owing to a jump in the secretion of the stomach's protective mucous.

Ghosal, S., et al, "Anti-ulcerogenic Activity of Fulvic Acids and 4-methoxy-6-carbmethoxybiphenyl Isolated From Shilajit," Phytotherapy Research, 2 (4): 187-191, 1988.

Two organic compounds, fulvic acid (FA) and 4-methoxy-6-carbmethoxybiphenyl (MCB), were extracted from shilajit for their ability to protect against ulcers. A single administration of the extracts did not offer protection from ulcer formation. Five consecutive days of administration of FA and MCB significantly reduced the stress-ulcer index compared with that of the control group.

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